Thermo Fisher Scientific beta Adducin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Peptide sequence:
VVNGREEEQT AEEILSKGLS QMTTSADTDV DTSKDKTESV TSGPMSPEGS

Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rabbit: 93%; Rat: 100%

Target Information

Adducins are heteromeric proteins composed of alpha, beta, and gamma subunits encoded by distinct genes. They are membrane skeletal proteins involved in spectrin-actin network assembly in erythrocytes and epithelial cell junctions.

• Alpha and gamma subunits are ubiquitously expressed.
• Beta subunit expression is restricted to brain and hematopoietic tissues.
• Adducin was first purified from human erythrocytes as an alpha-beta heterodimer.
• Polymorphisms in alpha and beta subunits are linked to blood pressure regulation in animal models.
• Each subunit has two domains: a protease-resistant globular N-terminal domain and a protease-sensitive C-terminal domain containing phosphorylation sites for protein kinase C, a calmodulin-binding site, and regions required for spectrin/actin association.
• Multiple alternatively spliced beta adducin mRNAs encoding different isoforms have been reported, though their specific functions remain unclear.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.