Thermo Fisher Scientific CCBE1 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
PMGPSPDLSH IKQGRRGPVG PPGAPGRDGS KGERGAPGPR GSPGPPGSFD

Sequence homology:
Cow: 100% | Dog: 100% | Guinea Pig: 100% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100% | Zebrafish: 100%

Target Information

The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region frequently deleted in breast and prostate cancers.
CCBE1 is a 406 amino acid secreted protein containing two collagen-like domains and one calcium-binding EGF-like domain.
EGF-like domains typically include six cysteine residues forming disulfide bonds. Calcium-binding EGF-like domains may undergo amino acid substitutions that alter structure or calcium affinity, affecting protein function.
Downregulation of CCBE1 is often observed in breast cancer, suggesting a role in cell adhesion and motility as an extracellular protein.
Three isoforms of CCBE1 are produced through alternative splicing events.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.