Thermo Fisher Scientific Human XAF1 Synthetic Peptide
Human XAF1 단백질의 카복시 말단 아미노산 서열에 해당하는 합성 펩타이드. XAF1 항체의 블로킹 펩타이드로 사용 가능. 인간 특이적 반응성을 가지며 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to amino acids at the carboxy terminus of human XAF-1.
PEP-0157 can be used as a blocking peptide with polyclonal antibody PA5-20038.
Target Information
The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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