Thermo Fisher Scientific CD137 (4-1BB) Polyclonal Antibody
CD137(4-1BB) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ELISA에 적합합니다. 인간, 생쥐, 랫드 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 면역학 및 T세포 활성화 연구용으로 추천됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human 4-1BB/CD137 (NP_0015522) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.51 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901579 |
Product Specific Information
- Positive Samples: Mouse spleen, Rat spleen
- Immunogen Sequence: DLSPGASSVT PPAPAREP
Target Information
CD137 (also known as 4-1BB or TNFRSF9) is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival of activated and memory CD8+ T cells, promotes clonal expansion, and modulates cytokine release influencing monocyte survival. Soluble CD137 may act as a negative regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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