Thermo Fisher Scientific HP1 alpha Polyclonal Antibody
Rabbit polyclonal antibody against HP1 alpha (CBX5) protein. Suitable for Western blot applications. Recognizes methylated histone H3 lysine-9 binding protein. Supplied as liquid, 0.5 mg/mL concentration. For research use only.
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Applications
- Western Blot (WB): 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (176 AYPEDAENKEKETAKS 191) of CBX5 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2540880 |
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. Mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in gene silencing and chromatin structure. High-affinity recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain, which acts as a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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