Thermo Fisher Scientific Phospho-FGFR1 (Tyr651, Tyr652) Polyclonal Antibody
Phospho-FGFR1 (Tyr651, Tyr652) 폴리클로날 항체로, 인간 FGFR1 단백질의 인산화 부위를 인식합니다. WB 및 IHC(P)에서 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids (644) RDIHHIDYYKKTTN (657) of human FGFR1, containing phosphorylated tyrosine residues at 651 and 652 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540876 |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors act as high-affinity receptors for 17 fibroblast growth factors (FGF1–17) and play critical roles in mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, resulting in multiple isoforms expressed differently during embryonic development and in adult tissues. Mutations or aberrations in FGFR1 are associated with several disorders, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal abnormalities involving FGFR1 are linked to stem cell myeloproliferative disorders and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
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