Thermo Fisher Scientific SOX1 Polyclonal Antibody
SOX1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 반응하며, Western blot에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태. 신경 분화 및 WNT 신호 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Horse, Human, Marsupial, Mouse, Non-human primate, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 100–150 of human SOX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540874 |
Target Information
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain.
SOX1 promotes neuronal cell fate determination and differentiation through multiple pathways.
It modulates LINE retroposons promoter activity and participates in central nervous system development, including neural and lens formation.
SOX1 binds directly to the HES1 promoter to suppress HES1 transcription, attenuating Notch signaling, and interacts with beta-catenin to suppress beta-catenin-mediated TCF/LEF signaling, potentially attenuating WNT pathway activity.
Expression of SOX1 is predominantly observed in embryonic tissues and moderately in the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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