Thermo Fisher Scientific TSC1 Monoclonal Antibody (OTI3A2), TrueMAB
인간 TSC1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 파라핀 조직 IHC에 적합합니다. 고순도 친화 크로마토그래피 정제, 무보존제 PBS 버퍼, 동결건조 형태로 제공되며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific TSC1 Monoclonal Antibody (OTI3A2), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 836–1164 of human TSC1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either the TSC1 or TSC2 tumor suppressor genes. These gene products form a protein complex that negatively regulates the mammalian Target of Rapamycin (TOR) pathway, which controls cell growth and cycle progression.
The TSC1/TSC2 complex stimulates Rheb GTPase activity, thereby reducing TOR activation. Overexpression of TSC1/TSC2 decreases the GTP/GDP ratio bound to Rheb, inhibiting cell proliferation. A shorter 40 kDa isoform of TSC1 has been identified, though its function remains unknown.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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