Thermo Fisher Scientific EGFR Monoclonal Antibody (OTI6E3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that mediates signaling in response to various growth factors. Overexpression of EGFR is associated with numerous cancers, making it a key target for biological and small-molecule therapeutics.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ERbB family of receptor tyrosine kinases, which includes ERbB2, ERbB3, and ERbB4.
EGFR activation occurs upon ligand binding (e.g., EGF, TGF-α), leading to receptor dimerization and autophosphorylation. Overexpression has been observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.