Thermo Fisher Scientific SKA1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Rhesus Monkey (94%), Bovine (87%)
• Positive Control: Target recombinant protein
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

During mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, enabling chromosome segregation. Kinetochores (KT) on centromeric chromatin are essential for proper chromosome attachment to spindle MTs.
The spindle and kinetochore complex (SKA complex), composed of SKA1, SKA2, and SKA3, is required for stable KT-MT interactions and timely anaphase onset.
Depletion of SKA1 or SKA2 by siRNA removes both proteins from the KT without altering overall KT structure. Cells lacking the SKA complex experience a prolonged metaphase-like delay, highlighting its role in maintaining the metaphase plate and spindle checkpoint silencing.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.