Thermo Fisher Scientific SKA1 Polyclonal Antibody
SKA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. IHC(P)에서 1:100~1:1,000 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 분열 시 방추체 형성과 키네토코어 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SKA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792596 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Rhesus Monkey (94%), Bovine (87%)
- Positive Control: Target recombinant protein
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
During mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, enabling chromosome segregation. Kinetochores (KT) on centromeric chromatin are essential for proper chromosome attachment to spindle MTs.
The spindle and kinetochore complex (SKA complex), composed of SKA1, SKA2, and SKA3, is required for stable KT-MT interactions and timely anaphase onset.
Depletion of SKA1 or SKA2 by siRNA removes both proteins from the KT without altering overall KT structure. Cells lacking the SKA complex experience a prolonged metaphase-like delay, highlighting its role in maintaining the metaphase plate and spindle checkpoint silencing.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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