Thermo Fisher Scientific Phosphoserine/threonine Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Positive test controls include: C6.

Target Information

Signal transduction pathways often involve reversible phosphorylation of serine and threonine residues within specific motifs of target proteins. These motifs are recognized by protein kinases and phosphorylation-dependent binding proteins such as 14-3-3. Such domains are crucial for modulating and amplifying intracellular communication.
Key kinases like Akt, RSK1, p70 S6K, and PKC isoforms are regulated by phosphorylation at serine or threonine sites surrounded by phenylalanine or tyrosine residues, which are essential for kinase activity.
The (Ser/Thr) Phe Antibody serves as a powerful tool for identifying proteins containing these regulatory motifs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.