Thermo Fisher Scientific HORMAD2 Monoclonal Antibody (OTI2E2), TrueMAB
인간 HORMAD2 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot에 적합하며, 동결건조 형태로 제공. 1 mg/mL 농도, PBS 및 trehalose 버퍼. 생식세포 감시 및 ATR 활성 연구용에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E2 |
| Immunogen | Full length human recombinant protein of human HORMAD2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint. Required for efficient build-up of ATR activity on unsynapsed chromosome regions, contributing to meiotic silencing of unsynapsed chromatin (MSUC) and meiotic quality control. Also necessary for BRCA1-dependent ATR activation on sex chromosomes, essential for normal sex body formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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