Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Thermo Fisher Scientific FANCD2 Polyclonal Antibody는 인간 FANCD2 단백질을 인식하는 고품질 항체로, WB, IHC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific FANCD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1401–1451 of human Fanconi anemia, complementation group D2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Monkey and Gorilla.
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis and is involved in the repair of DNA double-stranded breaks via homologous recombination and single-stranded annealing. FANCD2 is necessary for targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress and promotes BRCA2/FANCD1 loading onto damaged chromatin.
Defects in the FANCD2 gene result in Fanconi anemia complementation group D2, a disorder affecting all bone marrow elements and causing anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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