Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI2D3), Biotin, TrueMAB
Human ESR1 단백질을 인식하는 Mouse IgG1 단클론 항체로 Biotin 결합형 제품입니다. ELISA 및 Luminex 분석에 적합하며, 고순도 Affinity chromatography로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications
ELISA
- Tested Dilution: 1:250–1:1,000
Luminex
- Tested Dilution: Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D3 |
| Immunogen | Full-length human recombinant ESR1 protein produced in HEK293T cells |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon binding to estrogen, undergoes conformational changes enabling dimerization and DNA binding to estrogen response elements (ERE). This interaction regulates gene transcription through coactivator or corepressor recruitment.
There are two receptor forms, alpha (ESR1) and beta (ESR2), encoded by separate genes. Alternative RNA splicing produces at least four ESR1 isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa). Estrogen receptors are expressed in various tissues and are vital for sexual development, reproductive function, and bone health. They are implicated in diseases such as breast and endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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