Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI1B1), Biotin, TrueMAB
Human ESR1(Estrogen Receptor alpha) 단백질을 인식하는 mouse monoclonal antibody. Biotin으로 conjugation되어 ELISA 및 Luminex 분석에 최적화. 고순도 affinity chromatography 정제, 안정적인 PBS/BSA/glycerol buffer로 보관 용이.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| ELISA | 1:250–1:1,000 | |
| Luminex | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Full length human recombinant protein of human ESR1 produced in HEK293T cell |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 10 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, induces a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can regulate gene transcription by recruiting coactivator or corepressor proteins.
There are two main forms, alpha (ESR1) and beta (ESR2), encoded by separate genes. Due to alternative RNA splicing, at least four estrogen receptor-alpha isoforms exist (66 kDa, 53 kDa, 47 kDa, 35 kDa).
Estrogen receptors are widely expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone metabolism. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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