Thermo Fisher Scientific Androgen Receptor Recombinant Rabbit Monoclonal Antibody (PO00-29)
Androgen Receptor(AR)을 인식하는 재조합 토끼 단클론 항체로 Western blot 및 IHC(P) 검증 완료. Human 및 Rat 시료에 반응하며, Protein A 정제 및 PBS buffer(40% glycerol, 0.1% BSA)로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PO00-29 |
| Immunogen | Synthetic peptide within Human Androgen Receptor aa 300–400 (N-terminal) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931112 |
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor (~90 kDa) has three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. AR is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
The AR signaling pathway is essential for the development and function of male reproductive organs (prostate, epididymis) and also plays roles in muscle, hair follicles, and brain. AR is a phosphoprotein and regulates MAP kinase pathways. Dysregulation of AR signaling is associated with prostate cancer, Kennedy’s disease, male infertility, and complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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