Thermo Fisher Scientific MARCH1 Polyclonal Antibody
MARCH1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity chromatography 정제 항체입니다. PBS/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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- PA5103815
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MARCH1 (Accession Q8TCQ1), corresponding to amino acid residues V223–A273. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853148 |
Product Specific Information
Antibody detects endogenous levels of total MARCH1.
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS, and MHC class II proteins (such as HLA-DR alpha and beta), promoting their endocytosis and lysosomal sorting via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, MARCH1 down-regulates their surface localization, sequestering them in the intracellular endosomal system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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