Thermo Fisher Scientific NR4A3 Monoclonal Antibody (OTI2B11), TrueMAB

Thermo Fisher Scientific NR4A3 Monoclonal Antibody (OTI2B11), TrueMAB

Applications and Tested Dilution

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

NOR-1 (NR4A3) is a nerve growth factor-like receptor involved in:

• Neuronal development
• T-cell apoptosis
• Cancer progression

NOR-1 binds to the NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene.
It is rapidly but transiently induced by various stimuli. Downregulation of NOR-1 and other NGFI-B family members is associated with drug addiction-prone behavior in Lewis rats.
Three human protein isoforms have been documented: NOR-1, NOR-1β, and NOR-1 3′ variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.