Thermo Fisher Scientific Insulinoma Associated 2/INSM2 Monoclonal Antibody (INSM2, 4291)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

IA-6, also known as insulinoma-associated 2 (INSM2), is related to IA-1 (INSM1), a zinc-finger factor expressed in the developing nervous system.
While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes.
The homology exhibited by IA-6 to IA-1 suggests that IA-6 may also play a role in the regulation of gene transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.