
Thermo Fisher Scientific MB21D1 Monoclonal Antibody (7E3)
인간 MB21D1(cGAS) 단백질을 인식하는 마우스 모노클로날 항체로 Western blot에 적합. KLH 결합 합성 펩타이드로 면역화하여 제작. 단백질 G로 정제된 액상 항체이며, TBS 버퍼(40% glycerol, 1% BSA) 내 저장. 연구용으로만 사용 가능.
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Thermo Fisher Scientific MB21D1 Monoclonal Antibody (7E3)
Applications
- Western Blot (WB)
Tested Dilution
- 1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E3 |
| Immunogen | Mouse immunized with a KLH-conjugated synthetic peptide (amino acids 1–185 from human MB21D1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
cGAS (Cyclic GMP-AMP synthase) is a nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP, playing a key role in innate immunity. It binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, which subsequently activates TMEM173/STING to trigger type-I interferon production. cGAS is involved in innate immune sensing of infection, detection of bacterial DNA, response to cellular stress, DNA damage, and regulation of cellular senescence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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