Thermo Fisher Scientific CYLD Monoclonal Antibody (7C1)
인간 CYLD 단백질을 인식하는 Mouse monoclonal antibody. Western blot과 Flow cytometry에 최적화. Protein G로 정제된 액상 형태로, 안정적 보관 가능. 종양 억제 단백질 CYLD 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Flow Cytometry (Flow) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7C1 |
| Immunogen | This CYLD antibody is generated from a mouse immunized with a KLH-conjugated synthetic peptide corresponding to amino acids 305–582 of human CYLD (UniProt ID: Q9NQC7-1). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 40% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH. CYLD functions as a tumor suppressor protein that modulates the JNK signaling pathway and negatively regulates TRAF2 and NF-κB signaling. It also influences the IκB kinase pathway and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. TRAP1 is a known substrate for CYLD deubiquitination. Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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