Thermo Fisher Scientific Estrogen Receptor, alpha (ER alpha) Monoclonal Antibody (ERA)
인체 에스트로겐 수용체 알파(ERα)를 검출하는 단클론 항체로, Western blot 및 IHC(파라핀) 적용 가능. 고순도 Protein A 정제, 액상 형태로 제공되며 안정화 PBS 버퍼 포함. 유방암 등 ER 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ERA |
| Immunogen | A synthetic peptide corresponding to the C-terminus of human Estrogen Receptor Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Breast carcinoma
- Cellular location: Nucleus, Cytoplasm, Cell membrane
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding allows ER to regulate gene transcription through coactivator or corepressor proteins.
There are two forms of estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing generates at least four alpha isoforms (66 kDa, 53 kDa, 47 kDa, 35 kDa).
Estrogen receptors are widely expressed and play key roles in sexual development, reproductive function, bone physiology, and pathological processes such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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