Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI1H3), TrueMAB
NAB2 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. 인간 시료 반응성. 1 mg/mL 액상 형태로 제공되며 PBS, BSA, 글리세롤 완충액에 보관. -20°C에서 보관하며 반복 동결 해동은 피해야 함.
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Applications and Tested Dilution
- Western Blot (WB): 1:2,000 dilution tested
- Publications: Refer to related literature for usage examples.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). The conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A.
Both contain an N-terminal NAB conserved domain 1 (NCD1), essential for NGFI-A binding, and a C-terminal NCD2 domain responsible for repressor function. NAB2 is primarily localized in the nucleus and may play roles in downregulation of NGFI-A activity and in controlling cell division, differentiation, and apoptosis.
NAB2 has a predicted molecular mass of 56 kDa and is located on chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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