Thermo Fisher Scientific NAB2 Monoclonal Antibody (OTI1E12), TrueMAB
인간 NAB2 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot 및 IHC(Paraffin) 실험에 적합합니다. 액상 형태로 1 mg/mL 농도이며, PBS/BSA/glycerol buffer에 보존됩니다. 핵 내 NAB2 단백질 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 178–442 of human NAB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), required for binding NGFI-A, and a carboxy terminal NCD2 domain, responsible for the repressor function.
NAB2 is localized in the nucleus and may play roles in downregulation of NGFI-A activity, cell division, differentiation, and apoptosis.
NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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