Thermo Fisher Scientific TRPC4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 4.75 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, canine, human, mouse, and porcine based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 32,000.

Target Information

TRPC4 is a member of the canonical subfamily of transient receptor potential cation channels.
It forms a non-selective calcium-permeable cation channel activated by Gq-coupled receptors and tyrosine kinases.
TRPC4 plays roles in endothelial permeability, vasodilation, neurotransmitter release, and cell proliferation.
Single nucleotide polymorphisms in TRPC4 may be associated with generalized epilepsy with photosensitivity.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for TRPC4.

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel.
TRPC channels have seven TRPC genes (TRPC1–7) that encode channel proteins.
Diseases associated with TRPC4 include Photosensitive Epilepsy.

CaV3.3 encodes the pore-forming alpha subunit of a voltage-gated calcium channel.
The encoded protein is a low voltage-activated, T-type calcium channel characterized by slower activation and inactivation compared to other T-type channels.
CaV3.3 may be involved in calcium signaling in neurons.
Alternate splicing results in multiple transcript variants of CaV3.3.
Voltage-gated calcium channels (CaV) mediate calcium influx in response to depolarization and regulate intracellular processes such as contraction, secretion, neurotransmission, and gene expression.
Diseases associated with CACNA1I include Childhood Absence Epilepsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.