Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody
인간 Apolipoprotein B를 인식하는 염소 유래 polyclonal 항체로, WB 및 IHC(P) 실험에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 고순도 액상 형태로 제공됩니다. LDL 관련 연구 및 지질대사 연구용으로 최적화된 항체입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TDLHLRYQKDKK) corresponding to internal amino acids of APOB (aa 3984–3996) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10977051 |
Product Specific Information
This antibody is tested in Peptide ELISA with an antibody detection limit dilution of 32,000.
Target Information
Apolipoprotein B (apo B) in human plasma is a major protein of low-density lipoproteins (LDL) with a molecular mass of approximately 260–500 kDa. Apo B binds to specific receptors on cell membranes and is involved in the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL acts as a carrier protein for cholesterol in the blood and mediates uptake and clearance of cholesterol via receptor binding on capillary walls.
Oxidatively modified LDL is present in atherosclerotic lesions and is recognized by macrophages through scavenger receptors A and CD36.
Apolipoprotein B is synthesized mainly in the liver and exists as two isoforms, apoB-48 and apoB-100, encoded by a single gene.
Mutations in the Apolipoprotein B gene or its regulatory region can cause disorders such as hypobetalipoproteinemia and hypercholesterolemia.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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