Thermo Fisher Scientific NUP98 Polyclonal Antibody
인간 NUP98 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
- Publications: References
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NUP98 (Accession P52948), corresponding to amino acid residues L552–L602 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900315 |
Product Specific Information
This antibody detects endogenous levels of total NUP98.
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is composed of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated via synthesis and proteolytic cleavage of a 186 kDa precursor, yielding both 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC. Studies indicate the 98 kDa nucleoporin functions as a docking site for transport substrates.
The human NUP98 gene may fuse with other genes in certain leukemias (AML, T-ALL) and is located in the imprinted gene domain of 11p15.5, a key tumor-suppressor region associated with various cancers and syndromes such as Beckwith-Wiedemann syndrome. Alternative splicing results in several transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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