Thermo Fisher Scientific WNT10A Polyclonal Antibody
WNT10A 단백질을 인식하는 토끼 폴리클로날 항체로, IHC(P)에서 5 µg/mL 농도로 검증됨. 인간 및 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. WNT 신호 경로 연구 및 암 관련 단백질 발현 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from internal region of human WNT10A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551665 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Panda, Bovine, Dog, Rabbit (100%); Elephant, Bat (94%).
Target Information
The WNT gene family consists of structurally related genes encoding secreted signaling proteins. These proteins are implicated in oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis.
WNT10A is strongly expressed in promyelocytic leukemia and Burkitt’s lymphoma cell lines. It is coexpressed with WNT6 in colorectal cancer cell lines. Overexpression may play key roles in carcinogenesis through activation of the WNT–β-catenin–TCF signaling pathway. Both WNT10A and WNT6 genes are clustered in the chromosome 2q35 region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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