Thermo Fisher Scientific WNT1 Polyclonal Antibody

Thermo Fisher Scientific WNT1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 5 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Bat, Horse, Rabbit, Pig (100%).

Target Information

Wnt proteins constitute a family of secreted glycoproteins that activate signal transduction pathways to mediate tissue homeostasis, cell fate, cell proliferation, and self-renewal.
The canonical signaling pathway is initiated upon Wnt binding to a Frizzled family receptor and an LRP5/LRP6 coreceptor, leading to activation of the beta-catenin cascade.
Non-canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor.
Deregulation of these pathways or their components can lead to cancer.

Human Wnt-1 is encoded as a 370 amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form.
At the amino acid level, mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1.
Depending on the tissue, Wnt-1 can activate both canonical and non-canonical signaling pathways.
Studies have demonstrated its involvement in embryonic development and carcinogenesis.
Wnt-1 signaling can also induce phosphorylation and subsequent degradation of c-Myb.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.