Thermo Fisher Scientific Cullin 3 Polyclonal Antibody
Thermo Fisher Scientific의 Cullin 3 Polyclonal Antibody는 인간과 생쥐 시료에 반응하는 고품질 Rabbit IgG 항체입니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 적합하며, 고순도의 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Flow Cytometry (Flow) | 1:50–1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human Cullin-3 aa 724–768 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913209 |
Product Specific Information
- Positive Control: SH-SY5Y, 293T, mouse testis tissue lysate, human kidney tissue, human placenta tissue
- Subcellular Location: Golgi apparatus, Nucleus
Target Information
Cullin 3 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene.
CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc 53 (known as Cul A), these three subunits form a ubiquitin ligase complex that controls proteolysis of G1 cell cycle regulatory proteins.
In contrast to CUL 1, CUL 2 does not associate with p19 skp1 and p45 skp2. Instead, CUL 2 forms a complex with an inactive transcriptional elongation complex, SIII, composed of Elongin C, Elongin B, and VHL. The function of this association remains unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-119636_Cullin_3_Q13618-1_Rabbit.svg)
(PA5-119636_Cullin_3_Q13618-1_Rabbit_PDP.jpeg)
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