Thermo Fisher Scientific CDK11A/CDK11B Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CDK11A(Accession Q9UQ88), corresponding to amino acid residues D212-D262. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDK11A/CDK11B,uniProtId:Q9UQ88-1,ncbiNodeId:9606,antigenRange:212-262,antigenLength:783,antigenImageFileName:PA5-101273_CDK11ACDK11B_Q9UQ88-1_Rabbit.svg,antigenImageFileNamePDP:PA5-101273_CDK11ACDK11B_Q9UQ88-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2850712

Product Specific Information

Antibody detects endogenous levels of total CDK11.

Target Information

CDK11 is a member of the cyclin-dependent kinase 11 family which is known to be essential for eukaryotic cell cycle control and it is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. CDK11 is a negative regulator of normal cell cycle progression and Its expression is regulated during murine embryogenesis, and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle. CDK11 gene may harbor 1 or more tumor suppressor genes that affected by chromosome 1p36 modifications in neuroblastoma. CDK11 could be cleaved by caspases and was demonstrated to play roles in cell apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.