Thermo Fisher Scientific CHKB Polyclonal Antibody
CHKB 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 사용 가능. 인체 유래 항원 기반으로 제작되었으며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관, 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHKB (Accession Q9Y259), corresponding to amino acid residues P304–G354 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850713 |
Product Specific Information
Antibody detects endogenous levels of total CHKB.
Target Information
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase, the initial enzyme in the sequence, plays a role in cell growth and proliferation. A related protein, ChoKB (also known as choline kinase beta), is a 395 amino acid enzyme that catalyzes the phosphorylation of choline by ATP in the presence of magnesium, yielding phosphocholine and ADP. Like all choline kinases, ChoKB possesses ethanolamine kinase activity and catalyzes the phosphorylation of ethanolamine. The gene encoding ChoKB is located less than 1 kb upstream of the CPT1B gene, suggesting that ChoKB may regulate CPT1B transcription. In mice, mutations or deletions in the ChoKB gene cause hindlimb muscular dystrophy and neonatal bone deformity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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