Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (UMAB14), UltraMAB
Beta-catenin 단백질을 인식하는 고특이적 Mouse Monoclonal 항체로, Western blot, IHC, ICC/IF, Flow cytometry, ChIP 등 다양한 응용에 적합. Human, Mouse, Rat, Dog 반응성. 고순도 Affinity chromatography 정제, 안정적 PBS/BSA/glycerol buffer 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB14 |
| Immunogen | Full-length human recombinant protein of human CTNNB1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Beta-catenin is an adherens junction (AJ) protein, identified as a component of cell-cell adhesion structures. AJs are essential for maintaining epithelial cell layers by regulating growth and adhesion. Beta-catenin interacts with E-cadherin and alpha-catenin, linking them to the cortical actin cytoskeleton. It also associates with complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin is expressed in various hair follicle cell types and epithelial structures. Dysregulation of beta-catenin has been implicated in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other tumor developments. In the nucleus, beta-catenin coactivates Lef/Tcf transcription factors, stimulating genes like cyclin D and c-myc that promote cell proliferation. This activity underlies its role in tumorigenesis across multiple solid tissues including breast, colon, liver, lung, gastric, prostate, and skin.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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