Thermo Fisher Scientific PYGL Polyclonal Antibody
Thermo Fisher Scientific의 PYGL Polyclonal Antibody는 인간 및 영장류 시료에서 PYGL 단백질 검출에 적합한 항체입니다. IHC(P)에서 10 µg/mL로 사용되며, 항원 친화 크로마토그래피로 정제되었습니다. 장기 보관 시 -20°C에서 보관을 권장합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from C-terminus of human PYGL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551498 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%).
Target Information
This gene encodes a homodimeric protein that catalyzes the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores.
This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15.
Activity of this enzyme is regulated by multiple allosteric effectors and hormonal controls.
Humans have three glycogen phosphorylase genes that encode distinct isozymes primarily expressed in liver, brain, and muscle, respectively.
The liver isozyme serves the glycemic demands of the body, while the brain and muscle isozymes supply those tissues specifically.
In glycogen storage disease type VI (Hers disease), mutations in liver glycogen phosphorylase inhibit glycogen conversion to glucose, resulting in moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly.
Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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