Thermo Fisher Scientific TOM70 Polyclonal Antibody
TOM70 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 시료에 반응합니다. WB, ICC/IF, ELISA에 적합하며, 고순도 Affinity Chromatography로 정제되었습니다. 미토콘드리아 외막 단백질 연구용으로 사용됩니다.
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Thermo Fisher Scientific TOM70 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 245–608 of human TOM70 (NP_0556353) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806405 |
Product Specific Information
Immunogen sequence:
KNREPLMPSP QFIKSYFSSF TDDIISQPML KGEKSDEDKD KEGEALEVKE NSGYLKAKQY MEEENYDKII SECSKEIDAE GKYMAEALLL RATFYLLIGN ANAAKPDLDK VISLKEANVK LRANALIKRG SMYMQQQQPL LSTQDFNMAA DIDPQNADVY HHRGQLKILL DQVEEAVADF DECIRLRPES ALAQAQKCFA LYRQAYTGNN SSQIQAAMKG FEEVIKKFPR CAEGYALYAQ ALTDQQQFGK ADEMYDKCID LEPDNATTYV HKGLLQLQWK QDLDRGLELI SKAIEIDNKC DFAYETMGTI EVQRGNMEKA IDMFNKAINL AKSEMEMAHL YSLCDAAHAQ TEVAKKYGLK PPTL
Positive Samples: Mouse liver, Rat brain, Rat liver
Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein
Target Information
Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs).
TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A plays a significant role in importing nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and uncoupling proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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