Thermo Fisher Scientific TOM70 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_0556353) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TOM70,uniProtId:O94826-1,ncbiNodeId:9606,antigenRange:245-608,antigenLength:608,antigenImageFileName:PA5-92197_TOM70_O94826-1_Rabbit.svg,antigenImageFileNamePDP:PA5-92197_TOM70_O94826-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806405

Product Specific Information

Immunogen sequence: KNREPLMPSP QFIKSYFSSF TDDIISQPML KGEKSDEDKD KEGEALEVKE NSGYLKAKQY MEEENYDKII SECSKEIDAE GKYMAEALLL RATFYLLIGN ANAAKPDLDK VISLKEANVK LRANALIKRG SMYMQQQQPL LSTQDFNMAA DIDPQNADVY HHRGQLKILL DQVEEAVADF DECIRLRPES ALAQAQKCFA LYRQAYTGNN SSQIQAAMKG FEEVIKKFPR CAEGYALYAQ ALTDQQQFGK ADEMYDKCID LEPDNATTYV HKGLLQLQWK QDLDRGLELI SKAIEIDNKC DFAYETMGTI EVQRGNMEKA IDMFNKAINL AKSEMEMAHL YSLCDAAHAQ TEVAKKYGLK PPTL

Positive Samples: Mouse liver, Rat brain, Rat liver; Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein

Target Information

Functional mitochondria require up to 1000 proteins to function properly, with 99% synthesized as precursors in the cytoplasm and transported into the mitochondria with the aid of cytosolic chaperones and mitochondrial translocators (import components). Proteins to be imported are chaperoned to the mitochondria by the cytosolic heat shock protein (cHSP70) and are immediately pursued by Translocators of the Outer Membrane (TOMs), followed by transient interactions of the unfolded proteins with Translocators of the Inner Membrane (TIMs). TOMM70A is ubiquitously expressed in human tissues and localizes in the mitochondria. TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.