Thermo Fisher Scientific p115-RhoGEF Polyclonal Antibody
Human p115-RhoGEF 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 4°C에서 보관. 세포 신호전달 및 GTPase 관련 연구에 적합.
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Thermo Fisher Scientific p115-RhoGEF Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 775 and 825 of human 115 kDa Rho guanine nucleotide exchange factor (ARHGEF1, UniProt ID: Q92888-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
The Ras superfamily of GTPases, including Ras, Rho/Rac, Sar, Rab, ARF, and Ran subfamilies, regulates various cellular processes such as cytoskeletal rearrangement, nuclear signaling, and cell growth. These GTPases act as molecular switches cycling between active (GTP-bound) and inactive (GDP-bound) forms, with activation mediated by guanine nucleotide exchange factors (GEFs).
Dbl-related proteins, such as FGD1, Lsc, RhoGEF p115, Lfc, Lbc, and Brx, catalyze GEF activity for specific Ras family members. RhoGEF p115 specifically activates Rho GTPases but not Rac, Cdc42, or Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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