Thermo Fisher Scientific Cyclin B1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as undiluted liquid.
• Dilute only prior to immediate use.

Antiserum specifically reacts with a 55–62 kDa Cyclin B1 protein from human, rat, and mouse tissue.
No reaction observed against other related cyclins.
Cross-reactivity with Cyclin B1 from other species may also occur.

Target Information

Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and essential for controlling the cell cycle at the G2/M transition.
It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF).
Two alternative transcripts exist: one constitutive and one cell cycle-regulated, expressed mainly during G2/M phase.
Cyclin B1 accumulates during G2 phase and is degraded at the end of mitosis via APC-dependent destruction.
Its degradation is required for cell cycle progression.
Cyclin B1 is overexpressed in several cancers, including breast, prostate, and non-small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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