Thermo Fisher Scientific Cyclin B1 Polyclonal Antibody
Cyclin B1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. WB, IHC, ELISA, IP 등 다양한 응용 가능. 비결합형 액상 항체로 -20°C에서 보관. 세포주기 G2/M 조절 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
| ELISA | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full-length fusion protein corresponding to the human Cyclin B1 gene (UniProt ID: P14635-1, antigen range: 1–433) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 80 mg/mL |
| Storage Buffer | Whole serum |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only prior to immediate use.
Antiserum specifically reacts with a 55–62 kDa Cyclin B1 protein from human, rat, and mouse tissue.
No reaction observed against other related cyclins.
Cross-reactivity with Cyclin B1 from other species may also occur.
Target Information
Cyclin B1 (CCNB1) is a regulatory protein involved in mitosis and essential for controlling the cell cycle at the G2/M transition.
It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF).
Two alternative transcripts exist: one constitutive and one cell cycle-regulated, expressed mainly during G2/M phase.
Cyclin B1 accumulates during G2 phase and is degraded at the end of mitosis via APC-dependent destruction.
Its degradation is required for cell cycle progression.
Cyclin B1 is overexpressed in several cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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