Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI10B1), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2; T-cell immunoglobulin and mucin-domain containing-3) is a 281 amino acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It contains an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 plays a key role in macrophage activation and autoimmune disease induction, regulating Th1-mediated immune responses and promoting immune tolerance.
Pathological relevance includes experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease that increases disease severity in mice.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.