Thermo Fisher Scientific TRPC6 Polyclonal Antibody
TRPC6 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot 및 유세포분석에 최적화. 인간 반응성, 비결합형 액상 형태로 제공. TRPC6 관련 신호전달 연구 및 질환 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Thermo Fisher Scientific TRPC6 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EKLSMEPNQEETN) corresponding to the C-terminus amino acids of TRPC6 (aa 918–931) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983614 |
Product Specific Information
- Predicted to react with bovine, canine, human, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:2000.
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. It is activated by diacylglycerol (DAG) and operates independently of protein kinase C. The TRPC6 gene is associated with focal segmental glomerulosclerosis 2 (FSGS2).
TRPC6 belongs to the mammalian transient receptor potential (TRP) superfamily, particularly the canonical TRPC family, which includes seven members activated through PLC-coupled receptors. Members of the TRPC3/6/7 subfamily can be activated by DAG analogs, suggesting a mechanism of activation via PLC-coupled receptors.
When expressed in transfected cells, TRPC6 acts as a non-selective, store-independent, receptor-activated cation channel. It is insensitive to IP3 activation and encodes endogenous DAG-activated receptor-operated cation channels in vivo.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음 또는 별도 제공되지 않음)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.