Thermo Fisher Scientific ERLIN2 Polyclonal Antibody
ERLIN2 단백질을 인식하는 Thermo Fisher Scientific의 goat 유래 polyclonal antibody. Western blot 및 IHC(Paraffin) 검증 완료. 인간 반응성, rat 예측 반응성. 고순도 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EDEPLETATKEN) corresponding to the C-terminus amino acids of ERLIN2 (aa 328–339) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10980016 |
Product Specific Information
- Predicted to react with rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 2,000.
Target Information
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.
It promotes sterol-accelerated ERAD of HMGCR, implicating an AMFR/gp78-containing ubiquitin ligase complex.
ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulating the SREBP signaling pathway.
The molecular weight of the ERLIN1/ERLIN2 complex is about 70 kDa.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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