Thermo Fisher Scientific ISG15 Monoclonal Antibody (T.991.5)

Applications

Product Specifications

Product Specific Information

• It is not recommended to aliquot this antibody.
• This antibody is not cross-reactive with other ubiquitin family members, including ubiquitin, SUMO-1, SUMO-2, SUMO-3, and NEDD8.

Target Information

Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MHC-restricted cytotoxicity.
Synthesis is stimulated by IFN-alpha, IFN-beta, or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
ISG15 is secreted by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins.
Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may amplify and direct some of the immunomodulatory effects of IFN-alpha or IFN-beta.
Mutations affecting the gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.