Thermo Fisher Scientific ISG15 Monoclonal Antibody (T.991.5)
Human ISG15 단백질을 인식하는 Rabbit monoclonal antibody (Clone T.991.5). Western blot 및 Immunoprecipitation에 적합. 다른 ubiquitin 계열 단백질과 교차 반응 없음. Affinity chromatography로 정제된 액상 형태로 제공.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunoprecipitation (IP) | 1:25 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | T.991.5 |
| Immunogen | Synthetic peptide corresponding to amino acids at the amino terminus of human ISG15 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 129 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10985811 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other ubiquitin family members, including ubiquitin, SUMO-1, SUMO-2, SUMO-3, and NEDD8.
Target Information
Ubiquitin-like protein ISG15 plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. It is secreted from monocytes in response to type I interferons and causes natural killer (NK)-cell proliferation and an augmentation of non-MHC-restricted cytotoxicity.
Synthesis is stimulated by IFN-alpha, IFN-beta, or IFN-omega, but not IFN-gamma. ISG15 expression is also induced by overexpression of interferon regulatory factors and by influenza B virus.
ISG15 is secreted by cell lines of monocyte, T-lymphocyte, B-lymphocyte, human fibroblasts, and epithelial origins.
Enhancement of NK cell proliferation, augmentation of non-major histocompatibility complex-restricted cytotoxicity, and induction of IFN-gamma from T cells identify ISG15 as a member of the cytokine cascade and suggest that it may amplify and direct some of the immunomodulatory effects of IFN-alpha or IFN-beta.
Mutations affecting the gene can result in Immunodeficiency 38, with basal ganglia calcification (IMD38).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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