Thermo Fisher Scientific ASAH1 Monoclonal Antibody (1A7)
ASAH1 단백질을 인식하는 Mouse IgG3 모노클로날 항체로, WB, IHC, ELISA에 적합. 인간 시료 반응성. 고순도 친화 크로마토그래피 정제. PBS buffer, 무보존제, -20°C 보관. 암 및 신경질환 관련 연구용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A7 |
| Immunogen | ASAH1 (NP_808592, 25–124 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PPWTEDCRKS TYPPSGPTYR GAVPWYTINL DLPPYKRWHE LMLDKAPMLK VIVNSLKNMI NTFVPSGKVM QVVDEKLPGL LGNFPGPFEE EMKGIAAVTD
Target Information
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid.
This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene have been linked to the lysosomal storage disorder Farber lipogranulomatosis and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. Related pathways include Innate Immune System and Sphingolipid metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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