Thermo Fisher Scientific ASAH1 Monoclonal Antibody (2C9)
ASAH1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse IgG3 단일클론 항체. Western blot, IHC, ELISA에 적합. 인간 시료 반응성. 액상 형태로 제공되며, PBS 버퍼 보존. 연구용으로만 사용 가능.
- 카탈로그번호
- H00000427-M01
- 판매단위
- pk
카탈로그
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C9 |
| Immunogen | ASAH1 (NP_808592, 25–124 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PPWTEDCRKS TYPPSGPTYR GAVPWYTINL DLPPYKRWHE LMLDKAPMLK VIVNSLKNMI NTFVPSGKVM QVVDEKLPGL LGNFPGPFEE EMKGIAAVTD
Target Information
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid.
This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression.
Mutations in this gene have been linked to the lysosomal storage disorder Farber lipogranulomatosis and the neuromuscular disorder spinal muscular atrophy with progressive myoclonic epilepsy.
Related pathways include Innate Immune System and Sphingolipid metabolism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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