Thermo Fisher Scientific GCN2 Polyclonal Antibody
Rabbit polyclonal antibody against human GCN2 (EIF2AK4). Detects target by Western blot at 0.1–0.5 µg/mL. Lyophilized form, reconstitutable to 500 µg/mL. Suitable for research on amino acid starvation and stress response pathways.
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Applications and Tested Dilution
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human GCN2 (870–888 aa, ATDHLAFSADSKQDDQTGD) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL (after reconstitution with 0.2 mL distilled water) |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2746310 |
Product Specific Information
The synthetic peptide sequence used as immunogen corresponds to amino acids 870–888 of human GCN2:
ATDHLAFSADSKQDDQTGD
Reconstitution with 0.2 mL of distilled water yields a final concentration of 500 µg/mL.
Target Information
EIF2AK4 (GCN2) is a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor-2 (eIF2α) in response to low amino acid availability. It plays a key role in activating the integrated stress response necessary for adaptation to amino acid starvation. Mutations in this gene are associated with pulmonary veno-occlusive disease 2.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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