Thermo Fisher Scientific CAMLG Polyclonal Antibody
Human CAMLG 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot과 IHC(Paraffin)에 적합합니다. Affinity chromatography로 정제된 액상 제품이며 PBS/glycerol buffer에 보존됩니다. 연구용으로만 사용 가능합니다.
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- PA5103675
- 판매단위
- pk
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Thermo Fisher Scientific CAMLG Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CAMLG (Accession P49069), corresponding to amino acid residues K209–R259 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853009 |
Product Specific Information
Antibody detects endogenous levels of total CAMLG.
Target Information
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.
The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium.
This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-103675_CAMLG_P49069-1_Rabbit.svg, PA5-103675_CAMLG_P49069-1_Rabbit_PDP.jpeg)
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