Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. Human 및 Mouse 반응성. Affinity chromatography로 정제된 1 mg/mL 액상 항체로, PBS(50% glycerol, 0.02% sodium azide) 용액에 보관. -20°C에서 보관하며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC25A13 (Accession Q9UJS0), corresponding to amino acid residues L603–K653 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853012 |
Product Specific Information
This antibody detects endogenous levels of total SLC25A13.
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein localized to the inner mitochondrial membrane. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
It contains three Solcar repeats and four EF-hand domains for calcium binding.
Mutations in SLC25A13 cause citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
- CTLN2: autosomal recessive urea cycle disorder with neuropsychiatric symptoms (memory loss, seizures, coma).
- NICCD: non-lethal infant disorder with low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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