Thermo Fisher Scientific BCL2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.

The antibody is directed against human Bcl-2 and is useful in determining its presence in various assays.

Target Information

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death.
The BCL-2 family members are characterized by their ability to dimerize, modulating apoptosis.
Bag1 forms a heterodimer with BCL-2 to enhance its anti-apoptotic effect.
Bax and Bak play critical roles in cytochrome c release from mitochondria, initiating apoptosis.
Constitutive expression of BCL2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
Overexpression of BCL-2 has been linked to human cancers including B-cell lymphoma and prostate cancer.
Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.