Thermo Fisher Scientific BCL2 Polyclonal Antibody
BCL2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트, 소 시료에 반응하며, 단백질 A 정제 및 액상 형태로 제공됩니다. 세포 사멸 조절 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 – 1:2,000 |
| ELISA | 1:10,000 – 1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This purified IgG antibody was prepared from rabbit serum by repeated immunizations with a synthetic peptide corresponding to amino acids 62–76 (RDPVARTSPLQTPAA) of human Bcl-2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
The antibody is directed against human Bcl-2 and is useful in determining its presence in various assays.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death.
The BCL-2 family members are characterized by their ability to dimerize, modulating apoptosis.
Bag1 forms a heterodimer with BCL-2 to enhance its anti-apoptotic effect.
Bax and Bak play critical roles in cytochrome c release from mitochondria, initiating apoptosis.
Constitutive expression of BCL2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma.
Overexpression of BCL-2 has been linked to human cancers including B-cell lymphoma and prostate cancer.
Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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