Thermo Fisher Scientific CD44 Monoclonal Antibody (1F4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
KGEYRTNPED IYPSNPTDDD C

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 functions as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It participates in lymphocyte activation, recirculation, and homing. CD44 expression may be upregulated in some carcinomas and is speculated to be related to metastatic potential.

It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate CD44 expression in response to certain stimuli.

Transcripts of the CD44 gene undergo complex alternative splicing, resulting in many functionally distinct isoforms. Alternative splicing contributes to the structural and functional diversity of CD44.

Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.