Thermo Fisher Scientific CD44 Monoclonal Antibody (1B12)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATSTSSNTIS AGWEPNEENE DERDRHLSFS GSGIDDDEDF ISSTISTTPR AFDHTKQNQD WTQWNPSHSN PEVLLQTTTR MTDVDRNGTT AYEGNWNPEA HPPLIHHEHH EEEETPHSTS TIQATPSSTT EETATQKEQW FGNRWHEGYR QTPREDSHST TGTAAASAHT SHPMQGRTTP SPEDSSWTDF FNPISHPMGR GHQAGRRMDM DSSHSTTLQP TANPNTGLVE DLDRTGPLSM TTQQSNSQSF STSHEGLEED KDHPTTSTLT SSNRNDVTGG RRDPNHSEGS TTLLEGYTSH YPHTKESRTF IPVTSAKTGS FGVTAVTVGD SNSNVNRSLS GDQDTFHPSG GSHTTHGSES DGHSHGSQEG GANTTSGPIR TPQIPEWLII LASLLALALI LAVCIAVNSR RRCGQKKKLV INSGNGAVED RKPSGLNGEA SKSQEMVHLV NKESSETPDQ FMTADETRNL QNVDMKIGV

Target Information

CD44 is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast.
It functions as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration.
CD44 plays roles in lymphocyte activation, recirculation, and homing. Expression can be upregulated in certain carcinomas, potentially linked to metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes.
Alternative splicing generates multiple isoforms with distinct functions.
Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.