Thermo Fisher Scientific MTBP Polyclonal Antibody
Rabbit polyclonal antibody targeting human MTBP (residues 122–139). Validated for Western blot. Suitable for studying MDM2-dependent TP53/p53 regulation and tumor cell migration. Supplied as liquid, unconjugated form, stored at -20°C.
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- PA112808
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- pk
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Applications
- Western Blot (WB): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 122–139 of human MTBP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076624 |
Product Specific Information
A suggested positive control for this product is K562 cell lysate.
Target Information
MTBP inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. The protein may play a role in MDM2-dependent TP53/p53 homeostasis in unstressed cells. It inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability and promoting MDM2-mediated ubiquitination of TP53/p53, leading to its degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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